Postdoctoral Researcher, Quantitative Systems Pharmacology - Fixed Term Contract

GSK is a global biopharma company aiming to positively impact the health of 2.5 billion people by the end of the decade. They are seeking a Postdoctoral Researcher in Quantitative Systems Pharmacology to build mechanistic mathematical models and collaborate with multidisciplinary teams to inform drug development and research programs.

Responsibilities

• Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritization and optimal trial design
• Develop and/or utilize state-of-the-art mathematical tools including knowledge of non-linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
• Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling
• Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross-matrix colleagues to inform research and development programs and improve our understanding of disease mechanisms
• Promote transparency and communicate R&D achievements through publications in appropriate scientific journals

Skills

• PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology
• Strong drive to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design
• Strong communication skills and demonstrated ability to work in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
• Prior experience with applications in pharmaceutical research and development is a plus
• Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infections diseases (e.g. HBV) is a plus

Benefits

• Annual bonus based on company performance
• Healthcare and wellbeing programmes
• Pension plan membership
• Shares and savings programme
• Health care and other insurance benefits (for employee and family)
• Retirement benefits
• Paid holidays
• Vacation
• Paid caregiver/parental and medical leave

Company Overview

Company H1B Sponsorship