Senior Director, US Pricing & Contracting

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Role Summary:

The Senior Director, U.S. Pricing & Contracting is a strategic and operational leader responsible for developing and executing pricing and contracting strategies that optimize patient access, portfolio value, and financial performance across U.S. channels. This role shapes pricing and access strategy across the product lifecycle and serves as a key advisor on trade-offs related to pricing, reimbursement, and access.

The role integrates pricing strategy, payer and provider contracting, government pricing compliance, gross-to-net (GTN) performance, and advanced analytics to support in-line and pipeline products across their lifecycle.

The role requires strong leadership, deep expertise in the U.S. market, and a demonstrated ability to bring products to market successfully in complex, highly regulated environments.

Primary Responsibilities include:

Enterprise Pricing & Contracting Strategy

Develop and lead U.S. pricing and contracting strategies across assets, including launch pricing, lifecycle management, and portfolio optimization

Establish pricing frameworks, governance processes, and decision-making forums to enable disciplined execution and compliance

Translate clinical, economic, and real-world evidence into differentiated pricing and access strategies

Provide strategic recommendations on pricing, reimbursement, and access trade-offs to support business objectives

Financial Leadership & GTN Management

Lead gross-to-net (GTN) strategy, including forecasting, modeling, and performance management across commercial and government channels

Develop robust pricing and contracting analytics, including payer landscape assessment and contract performance tracking

Partner with Finance to evaluate pricing and contracting scenarios and support accurate forecasting and revenue planning

Oversee development of financial models (rebates, discounts, pricing scenarios, share shifts) to inform decision-making

Ensure operational excellence in contract execution, including rebate processing, chargebacks, and claims adjudication

Government Pricing & Compliance

Provide oversight of government pricing calculations and reporting, including AMP, Best Price, ASP, 340B, FSS, Medicaid, and Medicare

Ensure compliance with federal and state pricing regulations and evolving policy requirements

Oversee reporting processes, audit readiness, and vendor coordination

Monitor legislative and regulatory developments and assess implications for pricing and access strategies

Leadership & Cross-Functional Influence

Partner closely with Market Access, HEOR, Finance, Legal, Compliance, Commercial, Medical, and Government Affairs teams

Serve as a strategic advisor on pricing, contracting, and access decisions across the organization

Engage with external stakeholders, including payers, GPOs, specialty pharmacies, and vendors

Build, lead, and develop a high-performing pricing and contracting team

Foster a culture of accountability, innovation, and continuous improvement, while managing resources in alignment with business priorities

Education and Skills Requirements:

Bachelor’s degree required (Finance, Economics, Business, or related field)

MBA or advanced degree strongly preferred

15+ years in the biotech or pharmaceutical industry

10+ years of progressive experience in U.S. Market Access, with deep expertise in pricing and contracting

Proven experience developing and executing pricing and contracting strategies across commercial and government channels

Strong understanding of Medicare, Medicaid, 340B, VA/DoD, and PBM contracting environments

Demonstrated success in GTN forecasting, financial modeling, and contract negotiation

Deep knowledge of government pricing regulations and compliance requirements

Strong strategic, financial, and analytical skills

Executive-level communication and stakeholder influence capabilities

Deep understanding of payer dynamics, reimbursement, and access pathways

Ability to lead in complex, highly regulated, and rapidly evolving environments

Demonstrated success leading cross-functional initiatives and influencing without authority

MA Pay Range
$241,000—$285,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.